{"url":"https://jojo2009.hatenadiary.org/entry/20150831/p3","image_url":null,"author_url":"https://blog.hatena.ne.jp/jojo2009/","html":"<iframe src=\"https://hatenablog-parts.com/embed?url=https%3A%2F%2Fjojo2009.hatenadiary.org%2Fentry%2F20150831%2Fp3\" title=\"6\u5869\u57fa\u53cd\u5fa9\u914d\u5217\u3068ALS - \u732b\u8349\u306e\u65e5\u8a18\" class=\"embed-card embed-blogcard\" scrolling=\"no\" frameborder=\"0\" style=\"display: block; width: 100%; height: 190px; max-width: 500px; margin: 10px 0px;\"></iframe>","provider_url":"https://hatena.blog","type":"rich","blog_url":"https://jojo2009.hatenadiary.org/","title":"6\u5869\u57fa\u53cd\u5fa9\u914d\u5217\u3068ALS","height":"190","version":"1.0","provider_name":"Hatena Blog","blog_title":"\u732b\u8349\u306e\u65e5\u8a18","author_name":"jojo2009","categories":["\u533b\u7642","\u751f\u7269\u5b66"],"description":"The C9orf72 repeat expansion disrupts nucleocytoplasmic transportKe Zhang, Nature (2015) doi:10.1038/nature14973 GGGGCC\u306e6\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304c\u7e70\u308a\u8fd4\u3059\u914d\u5217\u304c\u5897\u3048\u3066\u3044\u304f\u3068\u6838\u3068\u7d30\u80de\u8cea\u306e\u9593\u306e\u305f\u3093\u3071\u304f\u8cea\u306e\u8f38\u9001\u306b\u5f71\u97ff\u304c\u51fa\u308b\u3002RanGAP1\u30686\u5869\u57fa\u7e70\u308a\u8fd4\u3057\u914d\u5217\uff08HRE)\u306eRNA\u304c\u7d50\u5408\u3057\u3066\u7d30\u80de\u5185\u306e\u5c40\u5728\u304c\u7570\u5e38\u306b\u306a\u308b\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6838\u3078\u306e\u8f38\u9001\u304c\u6e1b\u5c11\u3057\u6838\u304b\u3089\u7d30\u80de\u8cea\u3078\u306e\u8f38\u9001\u304c\u5897\u3048\u308b\u3068\u795e\u7d4c\u7d30\u80de\u6b7b\u306b\u3064\u306a\u304c\u308b\u3002\u3053\u308c\u306fRanGAP1\u306e\u6b20\u640d\u3057\u305f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u7d30\u80de\u3068ALS\u60a3\u8005\u7531\u6765\u306eiPS\u7d30\u80de\u304b\u3089\u3064\u304f\u3063\u305f\u795e\u7d4c\u7d30\u80de\u3067\u2026","published":"2015-08-31 00:00:00","width":"100%"}