{"published":"2013-10-24 23:16:12","title":"\u30de\u30a4\u30b9\u30bf\u30f3\u6dfb\u4ed8\u6587\u66f8\u6539\u8a02","author_name":"nohmin","url":"https://nohmin.hatenadiary.org/entry/20131024/1382796972","blog_url":"https://nohmin.hatenadiary.org/","provider_url":"https://hatena.blog","author_url":"https://blog.hatena.ne.jp/nohmin/","version":"1.0","blog_title":"\u3058\u3083\u308b\u65e5\u8a18","image_url":null,"description":"\u4f75\u7528\u6ce8\u610f\u306b\u30b9\u30c1\u30ea\u30d9\u30f3\u30c8\u30fc\u30eb\u3092\u8ffd\u8a18\u3002\u30b9\u30c1\u30ea\u30da\u30f3\u30c8\u30fc\u30eb\u304cCYP3A4\u304a\u3088\u3073CYP2C19\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u672c\u5264\u53ca\u3073\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3002 \u540c\u3058\u304f\u30aa\u30e1\u30d7\u30e9\u30be\u30fc\u30eb\u7b49\u306eCYP2C19\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3082\u8ffd\u8a18\u3002\u672c\u5264\u6d3b\u6027\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u4e0a\u6607\u304c\u4e88\u60f3\u3055\u308c\u308b\u305f\u3081\u3002 \u540c\u3058\u304f\u30c7\u30ad\u30b9\u30c8\u30ed\u30e1\u30c8\u30eb\u30d5\u30a1\u30f3\u7b49\u306e\u4e3b\u306bCYP2D6\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u308b\u85ac\u5264\u3082\u8ffd\u8a18\u3002\u672c\u5264\u304cCYP2D6\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u3002 \u91cd\u5927\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u4e2d\u6bd2\u6027\u8868\u76ae\u58ca\u6b7b\u878d\u89e3\u75c7(Toxic Epidermal Necrolysis:TEN)\uff0c\u76ae\u819a\u7c98\u819c\u773c\u75c7\u5019\u7fa4(Stevens-Johnson\u75c7\u5019\u7fa4)\u3092\u8ffd\u8a18\u3002","width":"100%","height":"190","html":"<iframe src=\"https://hatenablog-parts.com/embed?url=https%3A%2F%2Fnohmin.hatenadiary.org%2Fentry%2F20131024%2F1382796972\" title=\"\u30de\u30a4\u30b9\u30bf\u30f3\u6dfb\u4ed8\u6587\u66f8\u6539\u8a02 - \u3058\u3083\u308b\u65e5\u8a18\" class=\"embed-card embed-blogcard\" scrolling=\"no\" frameborder=\"0\" style=\"display: block; width: 100%; height: 190px; max-width: 500px; margin: 10px 0px;\"></iframe>","provider_name":"Hatena Blog","categories":["DI"],"type":"rich"}